Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort : A nested case-control study

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Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort : A nested case-control study

Huang, Jiaqi (författare): Karolinska Institute

Zagai, Ulrika (författare): Karolinska Institutet,Karolinska Institute

Hallmans, Göran (författare): Umeå universitet,Umeå University,Institutionen för kostvetenskap

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Nyrén, Olof (författare): Karolinska Institute

Engstrand, Lars (författare): Karolinska Institutet,Karolinska Institute

Stolzenberg-Solomon, Rachael (författare): National Cancer Institute, USA

Duell, Eric J (författare): Catalan Institute of Oncology

Overvad, Kim (författare): Aarhus University

Katzke, Verena A (författare): German Cancer Research Centre,Bellvitge University Hospital-IDIBELL

Kaaks, Rudolf (författare): German Cancer Research Centre

Jenab, Mazda (författare): International Agency for Research on Cancer, World Health Organization

Park, Jin Young (författare): International Agency for Research on Cancer, World Health Organization

Murillo, Raul (författare): International Agency for Research on Cancer, World Health Organization

Trichopoulou, Antonia (författare): National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens

Lagiou, Pagona (författare): Harvard University,National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens

Bamia, Christina (författare): Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens

Bradbury, Kathryn E (författare): University of Oxford

Riboli, Elio (författare): Imperial College London

Aune, Dagfinn (författare): Imperial College London

Tsilidis, Konstantinos K. (författare): University of Ioannina,Imperial College London

Capellá, Gabriel (författare): Catalan Institute of Oncology

Agudo, Antonio (författare): Bellvitge University Hospital-IDIBELL

Krogh, Vittorio (författare): Istituto Nazionale dei Tumori

Palli, Domenico (författare): Cancer Research and Prevention Institute (ISPO)

Panico, Salvatore (författare): University of Naples Federico II

Weiderpass, Elisabete (författare): Karolinska Institutet,Karolinska Institute,Folkhälsan Research Center,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø

Tjønneland, Anne (författare): Danish Cancer Society

Olsen, Anja (författare): Danish Cancer Society

Martínez, Begoña (författare): Andalusian School Of Public Health (EASP)

Redondo-Sanchez, Daniel (författare): CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),University of Granada

Chirlaque, Maria Dolores (författare): Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP),University of Murcia

HM Peeters, Petra (författare): University Medical Center Utrecht

Regnér, Sara (författare): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups

Lindkvist, Björn (författare): Sahlgrenska University Hospital

Naccarati, Alessio (författare): Human Genetics Foundation (HuGeF)

Ardanaz, Eva (författare): CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)

Larrañaga, Nerea (författare): CIBER Epidemiology and Public Health (CIBERESP)

Boutron-Ruault, Marie-Christine (författare): Institut Gustave Roussy,University of Paris-Saclay,Centre for Research in Epidemiology and Population Health (CESP)

Rebours, Vinciane (författare): Paris Diderot University

Barré, Amélie (författare): University of Paris-Saclay

Bueno-De-Mesquita, Bas H. (författare): University Medical Center Utrecht,Imperial College London,National Institute for Public Health and the Environment (RIVM),University of Malaya

Ye, Weimin (författare): Karolinska Institutet,Umeå University,Karolinska Institute

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2017-02-23
2017
Engelska 9 s.
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 140:8, s. 1727-1735

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The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR = 0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR = 1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR = 0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR = 1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR = 5.66; 95% CI: 1.59, 20.19, p value for interaction < 0.01). Our findings provided evidence supporting the null association between H. pylori infection and pancreatic cancer risk in western European populations. However, the suggested association between chronic corpus atrophic gastritis and pancreatic cancer risk warrants independent verification in future studies, and, if confirmed, further studies on the underlying mechanisms.

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Av författaren/redakt...: Huang, Jiaqi; Zagai, Ulrika; Hallmans, Göran; Nyrén, Olof; Engstrand, Lars; Stolzenberg-Solo ...; visa fler...; Duell, Eric J; Overvad, Kim; Katzke, Verena A; Kaaks, Rudolf; Jenab, Mazda; Park, Jin Young; Murillo, Raul; Trichopoulou, An ...; Lagiou, Pagona; Bamia, Christina; Bradbury, Kathry ...; Riboli, Elio; Aune, Dagfinn; Tsilidis, Konsta ...; Capellá, Gabriel; Agudo, Antonio; Krogh, Vittorio; Palli, Domenico; Panico, Salvator ...; Weiderpass, Elis ...; Tjønneland, Anne; Olsen, Anja; Martínez, Begoña; Redondo-Sanchez, ...; Chirlaque, Maria ...; HM Peeters, Petr ...; Regnér, Sara; Lindkvist, Björn; Naccarati, Aless ...; Ardanaz, Eva; Larrañaga, Nerea; Boutron-Ruault, ...; Rebours, Vincian ...; Barré, Amélie; Bueno-De-Mesquit ...; Ye, Weimin; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: International Jo ...

Av lärosätet: Lunds universitet; Umeå universitet; Karolinska Institutet

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Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort : A nested case-control study

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